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von Willebrand Disease

vWD is an autosomal dominant transmitted disorder, which quantitatively and qualitatively affects the von Willebrand factor. The von Willebrand factor is used to anchor platelets to tissue in a high shear stress area of bleeding to help create an initial platelet plug.

Clinical signs of the most common type of vWD (Type 1) may include mucosal bleeding, epistaxis, soft tissue hemorrhage, and increased bleeding after dental extractions. More severe clinical signs are found in uncommon types (Type 2, 3, 4) of vWD. The clinical severity of vWD can be assessed by measuring the bleeding time.

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