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The peak and duration of insulin is affected by many things, including individual response, time of day, exercise, stress, sickness, and content of a meal (high-fat meals can lead to hypoglycemia).
Insulin reacts differently in individuals and the chart below is only a general guideline based upon insulin manufacturer information.

Types of insulin

Type Technical name Brand name Onset Peak Duration
Rapid-acting Lispro
Glulisine
Aspart
Humalog
Apidra
NovoLog
5-15 min
5-15 min
10-20 min
30-75 min
30-75 min
1-3 hrs
2-3 hrs
2-4hrs
3-5 hrs
Regular/Short-acting Humulin R
Novolin R
30-60 min 2-5 hrs 5-8  hrs
Inter-mediate acting NPHLente Humulin N
Novolin N
Humulin L
1-3 hrs 6-12 hrs 16-24 hrs
Long-acting Insulin glargine Humulin U
Lantus
6-10 hrs
1 hour
minimal
none
>20 hrs
24-28 hrs
Premixed Insulin lispro protamine/insulin lispro Humalog Mix50/50
Humalog Mix75/25
30-60 min 2-12 hrs up to 18 hrs
Insulin aspart protamine/insulin aspart Novolog Mix50/50
Novolog Mix75/30
 NPH insulin/regular insulin Humulin 70/30
Novolin 70/30

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